Emergence of terpene cyclization in Artemisia annua

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Emergence of terpene cyclization in Artemisia annua

The emergence of terpene cyclization was critical to the evolutionary expansion of chemical diversity yet remains unexplored. Here we report the first discovery of an epistatic network of residues that controls the onset of terpene cyclization in Artemisia annua. We begin with amorpha-4,11-diene synthase (ADS) and (E)-β-farnesene synthase (BFS), a pair of terpene synthases that produce cyclic o...

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ژورنال

عنوان ژورنال: Nature Communications

سال: 2015

ISSN: 2041-1723

DOI: 10.1038/ncomms7143